Atcc stands ready to support our customers needs during the coronavirus pandemic. Symptom onset begins 3 to 5 days after an animal bite, but can range from 1 to 14 days. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Rarely, capnocytophaga germs can spread to people through bites, scratches, or close contact from a dog or cat and may cause illness, including sepsis. List of prokaryotic names with standing in nomenclature. Capnocytophaga gingivalis definition of capnocytophaga. Capnocytophaga species cause rare but severe infection in humans. Aspartame as a source of essential phenylalanine for the. Capnocytophaga gingivalis general information the following information is not yet verified taxonomy family. To view the entire topic, please sign in or purchase a subscription official website of the johns hopkins antibiotic abx, hiv, diabetes, and psychiatry guides, powered by unbound medicine. Phenylalanine was essential for the growth of capnocytophaga gingivalis, eubacterium timidum, fusobacterium nucleatum, porphyromonas gingivalis, t. A gramnegative, microaerophilic, co2requiring gliding bacillus, which is found in normal oral flora and an opportunistic pathogen. Capnocytophaga sputigena bacteremia in a patient with chronic.
Capnocytophaga species are facultative anaerobic, capnophilic, fusiform, gramnegative bacilli exhibiting gliding motility. Capnocytophaga canimorsus is a gramnegative, capnophilic rod constituting normal bacterial flora of the oral cavity of dogs and cats. Our first job is to listen to and observe what our customers need, and meet those needs with quality products and services. Capnocytophaga, streptobacillus, gram negatives flashcards. The bacterium is a zoonotic agent and has been isolated from humans, infected by dog or cat bites, scratches, licks or simply exposure to dogs or cats. Two reference strains capnocytophaga gingivalis atcc 33624. The genus initially included three species on the basis of morphological, physiological and dna. Capnocytophaga is the name of a group of gramnegative bacteria that live in the mouth of some animals and humans. The production and properties of an aminopeptidase from capnocytophaga gingivalis were studied. Genetic structure of populations of porphyromonas gingivalis associated with periodontitis and other oral infections. Many laboratories still have difficulty correctly identifying this species.
Arare case of bacteremia due to capnocytophaga canimorsus kazumi kikuchi, 1 kazushi ehara, 1 atsuko miyasaka, 1 shinobu koyama, 1 yuji yaguchi, 1 kiyoko tamai, 1 mayumi mitsui, 1 shigeyuki notake, 1 kouichi muramatsu, 1. Meningitis due to capnocytophaga canimorsus after receipt. Capnocytophaga sputigena, capnocytophaga gingivalis, capnocytophaga. Capnocytophaga synonyms, capnocytophaga pronunciation, capnocytophaga translation, english dictionary definition of capnocytophaga. It forms black colonies on blood agar it is found in the oral cavity, where it is implicated in periodontal disease, as well as in the upper gastrointestinal tract, the respiratory tract and the colon. Capnocytophaga, a genus of gramnegative anaerobes that inhabit the oral cavity, has been reported to be an unusual cause of chorioamnionitis and neonatal infection. Infections caused by capnocytophaga species are infrequent, and specieslevel biochemical identification is difficult. Capnocytophaga gingivalis bacteremia detected only on quantitative blood cultures in a child with leukemia. Whole genome sequencing identifies a novel species of the. Capnocytophaga granulosa and capnocytophaga haemolytica. Normally found in the oropharyngeal tract of mammals, they are involved in the pathogenesis of some animal bite wounds and periodontal diseases. N2 we report the case of a 59yearold man with waldenstroms macroglobulinemia and active alcohol use who presented with bilateral knee pain 5 years after a bilateral.
Many capnocytophaga germs are normal bacteria commonly found in the mouths of people, dogs, and cats. Actinobacillus, aggregatibacter, kingella, cardiobacterium. Capnocytophaga canimorsus is the main human pathogen associated with dog bites. Capnocytophaga definition of capnocytophaga by the free. Sixtyeight strains of capnophilic fusiform gramnegative rods from the human oral cavity were subjected to extensive physiologic characterization, tested for susceptibility to various antibiotics, and the molpercent guanine plus cytosine of each isolate determined. Identify the major clinical diseases associated with actinobacillus, aggregatibacter, kingella, cardiobacterium, and capnocytophaga spp.
Capnocytophaga information for healthcare professionals. Ninetyseven strains of capnocytophaga isolated from the oral cavity and the type strains of c. Capnocytophaga sputigena bacteremia in a patient with. Capnocytophaga species constitute part of the normal oral microflora of humans and animals, and are often considered as opportunistic pathogens, that was confirmed by recent studies of microbial profiles using the human oral microbe identification microarray 23, 54, 128, 1. Antimicrobial treatment of capnocytophaga infections. It has been isolated from women with bacterial vaginosis. Explain the incubation conditions for the bacteria discussed in this chapter including oxygenation, time, and temperature. It is found in the oral cavity, where it is implicated in periodontal disease, as well as in the upper gastrointestinal tract, the respiratory tract and the colon. Pronunciation of capnocytophaga canimorsus with 1 audio pronunciation and more for capnocytophaga canimorsus. Pcr detection of capnocytophaga species in dental plaque. The genus initially included three species on the basis of morphological, physiological and dna data.
Porphyromonas gingivalis belongs to the phylum bacteroidetes and is a nonmotile, gramnegative, rodshaped, anaerobic, pathogenic bacterium. Capnocytophaga canimorsus is a commensal bacterium found in the saliva of 1624% of dogs and 17% of cats 1, 2. This is a pdf file of an unedited manuscript that has been accepted for publication. Capnocytophaga keratitis university of miamis research. Meningitis due to capnocytophaga canimorsus after receipt of. The role of capnocytophaga species in oral health and. Get a printable copy pdf file of the complete article 512k, or click on a page image below to browse page by page. Lin after 1961, a number of previously unidentified gramnegative bacilli were referred to the centers for disease control and prevention.
Capnocytophaga canimorsus, formerly known as dysgonic fermenter 2, is a slowly growing, capnophilic, fusiform, and filamentous gramnegative rod. A genus of bacteria comprising fusiform, fermentative, gramnegative rods which require carbon dioxide for growth and show gliding motility explanation of capnocytophaga canimorsus. The characteristics of the isolates were compared with 10 fresh and 2 stock isolates of fusobacterium nucleatum. Capnocytophaga gingivalis, capnocytophaga ochracea. Isolation of capnocytophaga species with a new selective medium. Many kinds of bacteria germs called capnocytophaga live in the mouths of dogs and cats. Capnocytophaga species constitute part of the normal oral microflora of. To atcc valued customers, atcc stands ready to support our customers needs during the coronavirus pandemic. Capnocytophaga should be included in the differential diagnosis of bacterial keratitis in patients with suggestive predisposing factors or with protracted keratitis unresponsive to treatment. Uniform attributes of the fusiform isolates include gliding motility, strictly fermentative metabolism dependent on the presence of co2 or hco 3, under either anaerobic or aerobic conditions, presence of benzidine. In 1976, light was shed on these unidentified bacilli when bobo and newton described a man who developed septicemia and meningitis after. Capnocytophaga canimorsus is the species most commonly involved in zoonotic.
The discovery and naming of capnocytophaga canimorsus. These germs sometimes cause opportunistic infections, which means under the right conditions they can cause an infection, such as in a person with a weakened immune system people with weakened immune systems include those who. Diagnosing capnocytophaga canimorsus infections volume 12. National surveillance for capnocytophaga species is not performed in the united states. Find out information about capnocytophaga canimorsus. In 1976, it was first reported to cause septicemia, endocarditis, and meningitis in humans. A patient with bacteraemia and possible endocarditis. Jun 19, 2014 although there is no consensus guideline for the treatment of capnocytophaga infections, the antibiotics to which capnocytophaga species are already known to be susceptible, such as clindamycin, imipenemcilastatin, and. Get a printable copy pdf file of the complete article 796k, or click on a page image below to browse page by page. We present two cases of infection caused by capnocytophaga ochracea.
This has been especially true amongst those with serious comorbidities and the immunocompromised populations. What is capnocytophaga how common is capnocytophaga. Capnocytophaga is a genus of gramnegative bacteria. Public health service guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. Capnocytophaga canimorsus was first described in 1976 by bobo and newton 1 and is a slowgrowing, gramnegative, and rodshaped bacterium belonging to the natural flora of the oral mucosa of dogs and cats.
The lipopolysaccharide from capnocytophaga canimorsus reveals. The more rarely identified species 15% capnocytophaga gingivalis, capnocytophaga. Role of dna gyrase and topoisomerase iv mutations in. They were the earliest bacteria to be isolated and named from the human subgingival plaque. Diversity of capnocytophaga species in children and description of. T2 capnocytophaga canimorsus a novel pathogen for joint arthroplasty. Capnocytophaga canimorsus article about capnocytophaga. Capnocytophaga canimorsus formerly cdc group df2 and capnocytophaga cynodegmi cdc group df2 like were proposed as two new species. Capnocytophaga species infectious disease and antimicrobial. It is part of the normal oral flora of dogs and cats and can cause human septicemia, usually after receipt of a dog bite or contact with dogs. Get a printable copy pdf file of the complete article 717k, or click on a page. Capnocytophaga cynodegmi and38 capnocytophaga canimorsus latin canis dog and latin morsus bite are part of the oral microbiota39 of canines and more rarely of cats. Capnocytophaga ochracea is an aerotolerant anaerobe that requires either an anaerobic environment or 5% co2 concentration of the gaseous form or 20 mm hco3 in the hydrated form 7.
Oct 07, 20 capnocytophaga cynodegmi and38 capnocytophaga canimorsus latin canis dog and latin morsus bite are part of the oral microbiota39 of canines and more rarely of cats. Capnocytophaga canimorsus definition of capnocytophaga. Capnocytophaga canimorsus is a commensal bacterium in the oral flora of dogs and cats. Although several species are known to cause human disease. Bacteria of the genus capnocytophaga are recently recognised pathogens which may cause oral disease and subsequent septicaemia in the immunocompromised host. Capnocytophaga are gramnegative, facultative anaerobic bacteria.
Capnocytophaga are a genus of bacteria that have been found to be the causative organisms in a range of infections, including serious conditions such as bacteraemia, endocarditis and meningitis. It is also considered to be an etiological factor of infections in human that may lead to. Whole genome sequencing identifies a novel species of the genus capnocytophaga isolated from dog and cat bite wounds in humans. Start studying capnocytophaga, streptobacillus, gram negatives. The genus capnocytophaga is a group of fusiform, gramnegative, rodshaped organisms with gliding motility whose growth is favoured by a capnophilic atmosphere. Capnocytophaga species have been implicated as putative periodontal pathogens. A compact cluster of sessile flowers, often surrounded by involucral bracts, as of daisies and other composite plants. Pdf identification of capnocytophaga species from oral cavity of. The word element capno in the bacteriums name refers to its ability to survive in high levels of carbon dioxide. What links here related changes upload file special pages permanent link page information. The bacterium is a zoonotic agent and has been isolated from humans, infected by dog or cat bites, scratches.
These organisms are part of the normal oral flora and were first described as bacteroides ochraceus and cdc group df1. Signs and symptoms of capnocytophaga infection can vary widely from skin to invasive infections. Capnocytophaga sputigena as separate species, and underlined the problems of distinguishing between them by. Capnocytophaga is the name of a group of gram negative bacteria that live in the mouth of some animals and humans. The first case of the infection in humans was reported by bobo and newton in 1976. Clinical findings c gingivalis may cause periodontal disease or, in immune compromised hosts e. In addition, they are opportunistic pathogens associated with periodontal diseases and animal bites, causing systemic infection in both immunocompetent and immunocompromised hosts 2, 3. Capnocytophaga ochracea, capnocytophaga sputigena and capnocytophaga gingivalis.
It is part of the normal oral flora of dogs and cats and can cause human septicemia, usually after. Most people who have contact with a dog or cat do not become sick. Capnocytophaga ochracea, capnocytophaga canimorsus, capnocytophaga cynodegmi, capnocytophaga gingivalis. The characteristics of gliding bacteria isolated from both healthy and diseased sites in the oral cavity are, summarized and the taxonomic position of the bacteria discussed. It is a slowly growing gramnegative bacillus that has been implicated in a variety of disorders including sepsis, meningitis, thrombotic thrombocytopenic purpura, and endocarditis 38. They are facultatively anaerobic and require enrichment with co2 510% for optimum growth capnophilic. Symptoms can progress rapidly from mild, localized infection to systemic infection, including sepsis, organ failure, meningitis, and disseminated. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Detection, identification, and comparison of capnocytophaga. Bacteremia by multidrugresistant capnocytophaga sputigena. The discovery and naming of capnocytophaga canimorsus jonathan y.
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